<x-charset iso-8859-1>I did a literature search and could not come up with any information on
vertical/transplacental infection with WNV, but did find some information on
the closely related Japanese Encephalitis virus:
Natl Inst Anim Health Q (Tokyo) 1983 Spring;23(1):21-6 Related Articles,
Links
Experimental studies on vertical infection of mice with Japanese
encephalitis virus. IV. Effect of virus strain on placental and fetal
infection.
Fujisaki Y, Miura Y, Sugimori T, Murakami Y, Miura K.
An experiment was carried out to examine the effect of an inoculated strain
of Japanese encephalitis virus on the establishment of experimental vertical
infection of mice with this virus. In it, closed-colony mice of the CFW
strain were inoculated intravenously with seven strains of the virus at 7
days of pregnancy. After that, an attempt was made to recover the virus from
placenta and fetus, so that the infection rate of each strain might be
determined. As a result, the infection rate was high for both placenta and
fetus in the case of the AS-6 and Sagara strains both of which had undergone
three passages in the mouse brain. The placental infection rate was high and
the fetal infection rate relatively low in the case of the JaGAr01 and Fuji
strains which had undergone 7 and 150 passages, respectively, in the mouse
brain. The infection rate was very low for both placenta and fetus in the
case of the Nakayama-Yakken strain which had undergone more than 100
passages in the mouse brain. There was no difference in the severity of
viremia after inoculation between the AS-6 and Fuji strains. Both placental
and fetal infection rates were low in the case of the JaTH160 strain which
had undergone passages in mice by intraperitoneal inoculation and which
presented a strong peripheral infectivity and induced a severe viremia after
inoculation. Neither placental nor fetal infection occurred in the case of
the S- strain used as live virus vaccine. These results indicated that
placental and fetal infection rates varied from one virus strain to another.
Acta Virol 1982 Jul;26(4):283-7 Related Articles, Links
Japanese encephalitis virus infection in fetal mice at different stages of
pregnancy. II. Resistance to Japanese encephalitis virus infection.
Miura T, Sugamata M, Ogata T, Matsuda R.
The relationship between the stage of pregnancy of mice at the time of
Japanese encephalitis (JE) virus inoculation and the resistance of JE virus
infection of their offsprings was investigated. It was found that there was
a stronger resistance to JE virus infection in offsprings born of mothers
inoculated with JE virus at nine to sixteen days before parturition than in
offsprings of mothers inoculated at one to eight days or at seventeen to
twenty days before parturition. Resistance of the offsprings to JE virus
infection lasted up to the age of 180 days after birth.
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Received on Thu Oct 17 11:17:53 2002
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