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WNV VACCINE for GEESE, FWD from ProMED
Date: Thurs, 7 Feb 2002
DEVELOPMENT & PRODUCTION of WEST NILE FEVER VACCINE for GEESE
Source:
Consequently, during 2001 about 900 000 doses of a killed WNV vaccine were produced and passed the testing procedures for safety, sterility, challenge trials and experimental field trials. The vaccine was released for field
use in August 2001; until the end of October, about 300 000 geese in commercial flocks were vaccinated twice, at 2 and 4 weeks of age. Field observations, as well as laboratory challenge trials carried out in sampled vaccinated geese, have confirmed the vaccine efficiency in field conditions.
The laboratory is continuing the production of the killed vaccine for field use in geese during 2002. It is also proceeding with the testing of various alternative systems for virus replication, in order to improve production
efficiency and to decrease the costs.
[Byline: I. Samina]
[see related articles on ProMED-mail's web site at (http://www.promedmail.org):
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Posted by: Environmental Risk Analysis Program (envrisk@cornell.edu)
Bi-monthly newsletter, Veterinary Services and Animal Health, Israel, Jan 2002
[translated from Hebrew by Mod.AD, edited]
In view of the losses caused by West Nile virus (WNV) to the Israeli goose industry since 1997, the State Laboratory for Vaccine Control in the Kimron Veterinary Institute (KVI) at Beit Dagan has been engaged in an effort to develop an efficient vaccine. Following preliminary trials involving virus replication in chicken eggs, various tissue cultures, suckling- and adult mice and day-old-chicks, the suckling-mouse system was found to be most suitable for vaccine production, though relatively laborious and costly.
West Nile virus, equine vaccine (02) 20010808.1867
West Nile virus, human - Israel 20010802.1510
West Nile virus, geese - Israel 19991123.2076]
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